Pharmacology
Mounjaro slows down the passage of food through the digestive tract, leading to satiety. It reduces appetite and food craving. It stimulates insulin production when needed. Thus, it lowers blood sugar level. It also reduces sugar secretion through liver. It improves insulin sensitivity, thus ensuring blood sugar control. It supports fat tissue loss.
Monjara is made from trizepatide, which mimics two hormanes — GLP1 and GIP.
Trizepatide is a prescription medicine meant for type 2 diabetics. It is also approved for weight loss in obese individuals. It is not for cosmetic weight loss.
Dosage
The starting dose is 2.5 mg once a week for four weeks. The dose is then increased to 5 mg weekly. The dose can be increased to 7.5 mg, 10 mg, 12 .5 mg and up to maximum 15 mg weekly. Each increase takes four weeks.
Side Effects
Gastrointestinal side effects — nausea, vomiting, diarrhea and constipation. As the body adapts, these lessen after three months.
Long-term Use
It is designed for long-term use. It reduces four per cent of body weight after one month and around six per cent after two months. It can reduce 20 per cent of body weight, equivalent to bariatric surgery.
On discontinuation, after 6 months the patient regains 14 per cent of the body weight. Majority of people could keep the weight off.
Once started, one cannot stop. There should be disciplined lifestyle.
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