Insulin is secreted by pancreas in response to the rise in blood sugar after the intake of any food.Incretins enhance insulin secretion after eating.In digestion, two hormones are secreted — Glucagon-like Peptide I or GLP 1 and glucose-dependent Insulinotropic Polypeptide or GIP. Both these hormones are dissolved within minutes after their secretion by another gastro-intestinal hormone — Dipeptidyl Peptidase 4 or DPP 4.

Incretins can be used to control blood sugar in patients with Type 2 diabetes. They can be given GLP 1 analogue or we can increase the activity of incretin by inhibiting DPP4.Insulin levels are increased.